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eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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4/2014
vol. 20
 
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abstract:
Case report

Response to low dose indomethacin in two children with nephrogenic diabetes insipidus

Devi Dayal
,
Savita Verma Attri
,
Anil Kumar Bhalla
,
Rakesh Kumar

Pediatr Endocrinol Diabetes Metab 2014;22,4:178-181
Online publish date: 2015/08/31
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Two children with nephrogenic diabetes insipidus (NDI) were treated with oral indomethacin (0.75-1.2 mg/kg/day) three times a day for a mean duration of 3 yrs. Remission occurred in both patients in terms of achieving a normal fluid balance and body growth and the drug was withdrawn in one patient after 2 yrs. The treatment was well tolerated and no side effects were noted. The mean duration of follow-up was 6.5 yrs. These long-term observations of a favourable response to low dose indomethacin in 2 children with NDI need to be tested on larger number of patients.
keywords:

nephrogenic diabetes insipidus, cyclooxygenase inhibitors, indomethacin, children


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