Association of PD-1 and PD-L1 protein expression with selected clinical and morphological parameters  in colorectal cancers

Paulina Poter; Sylwia Jankowska-Szabłowska; Tomasz Kolenda; Ewa Dobak; Elżbieta Urasińska; Katarzyna Karpińska-Łukaszewicz

doi:10.5114/pjp.2024.139935

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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abstract:

Original paper

Association of PD-1 and PD-L1 protein expression with selected clinical and morphological parameters in colorectal cancers

Paulina Poter

^{1, 2, 3}

,

Sylwia Jankowska-Szabłowska

³

,

Tomasz Kolenda

^{4, 5}

,

Ewa Dobak

³

,

Elżbieta Urasińska

³

,

Katarzyna Karpińska-Łukaszewicz

³

Department of Tumor Pathology, Greater Poland Cancer Centre, Poznań, Poland
Department of Oncologic Pathology and Prophylaxis, University of Medical Sciences, Poznań, Poland
Department of Pathology, Pomeranian Medical University, Szczecin, Poland
Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznań, Poland
Research and Implementation Unit, Greater Poland Cancer Centre, Poznań, Poland

Pol J Pathol 2024; 75 (2)

DOI: https://doi.org/10.5114/pjp.2024.139935

Online publish date: 2024/05/27

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Colorectal cancer is the third most common cancer worldwide and the second cause of death from malignant tumors. Colorectal cancers are treated with surgery, chemotherapy, gene therapy and immunotherapy. PD-1 and PD-L1 proteins have recently been considered as potential targets of anticancer therapy in colorectal cancer. The aim of this study was to evaluate the association of immunohistochemical expression of PD-1 and PD-L1 proteins in colorectal cancer patients with selected clinical and morphological parameters and their survival. Ninety-eight cases of colorectal cancer were studied. Immunohistochemistry was used to evaluate the expression of PD-1 and PD-L1 proteins. Correlations were found between the expression of PD-L1 protein in lymphocytes and lack of lymph node metastases and a lower clinical stage. There was also a correlation between PD-L1 protein expression in cancer cells and a higher grade of histological malignancy.

keywords:

Association of PD-1 and PD-L1 protein expression with selected clinical and morphological parameters in colorectal cancers

Paulina Poter 1, 2, 3 , Sylwia Jankowska-Szabłowska 3 , Tomasz Kolenda 4, 5 , Ewa Dobak 3 , Elżbieta Urasińska 3 , Katarzyna Karpińska-Łukaszewicz 3

colorectal cancer, PD-1, PD-L1

Paulina Poter

^{1, 2, 3}

,

Sylwia Jankowska-Szabłowska

³

,

Tomasz Kolenda

^{4, 5}

,

Ewa Dobak

³

,

Elżbieta Urasińska

³

,

Katarzyna Karpińska-Łukaszewicz

³