eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2024
vol. 41
 
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abstract:
Original paper

Expression and clinical significance of interleukin-10, transforming growth factor-b1, and CD4+CD25 cytokines in paediatric allergic rhinitis with allergic asthma

Jing Chen
1
,
Shuyu Wang
2
,
Yan Cheng
3
,
Fukun Wang
1
,
Xuechao Liu
4

  1. Department of Clinical Laboratory, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China
  2. Department of Paediatric Cardiology, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China
  3. Department of Basic Medical Laboratory, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China
  4. Department of Clinical Laboratory, Hebei Children’s Hospital Affiliated to Hebei Medical University, Shijiazhuang, Hebei Province, China
Adv Dermatol Allergol 2024; XLI (3): 276-283
DOI: https://doi.org/10.5114/ada.2024.140522
Online publish date: 2024/05/07
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Introduction:
It was intended to research the level changes and clinical significance of interleukin (IL)-10, transforming growth factor b1 (TGF-b1), and CD4+CD25 cytokines in paediatric allergic rhinitis (AR) accompanied with allergic asthma (AA).

Material and methods:
Eighty children of AA with AR receiving immunotherapy indications were included as the experimental group (EG), while another 40 healthy children in the same period were selected as the control group (CG). IL-10, TGF-b1, and CD4+CD25 levels in cells of the two groups before and after treatment were compared and analysed.

Results:
The serum TGF-b1 level was determined as 1,045.7 ±44.7 pg/ml in the EG at admission, remarkably higher than that in the CG (p < 0.05). The IL-10 level was 21.4 ±2.8 pg/ml; CD4+CD25 cells accounted for 9.2 ±2.4%, CD4+CD25high cells accounted for 0.6 ±0.3%. These were all greatly lower than those in the CG (p < 0.05). At discharge, the serum TGF-b1 level in the EG was 903.7 ±29.4 pg/ml, which was still memorably higher than that in the CG (p < 0.05). The IL-10 level changed to 32.8 ±3.7 pg/ml; the percentage of CD4+CD25 was 11.3 ±1.8, respectively, among CD4+T cells. These were also notably lower than those in the CG at discharge (p < 0.05).

Conclusions:
IL-10, TGF-b1, and CD4+CD25 level changes in cells might be of reference value as therapeutic indicators for clinical treatment or evaluation of paediatric AR with AA.

keywords:

paediatric allergic rhinitis, allergic asthma; interleukin-10, transforming growth factor b1, CD4+CD25
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